Implicaciones funcionales del sistema renina-angiotensina cerebral
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2017-10-31
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Jaén: Universidad de Jaén
Resumen
La investigación sobre el sistema renina-angiotensina (SRA) se ha centrado en el estudio del papel que ejercía el SRA circulante sobre el control de la presión arterial. Sin embargo, recientemente se demostró que los componentes del SRA se encontraban no sólo en sangre sino en otros tejidos como el cerebro donde ejerce funciones no sólo destinadas al incremento de la presión arterial sino que también participa en diversas funciones cerebrales incluyendo las cognitivas. Un conocimiento profundo del SRA cerebral nos permitirá obtener importantes sugerencias sobre posibilidades terapéuticas no sólo para el tratamiento de la hipertensión sino para el tratamiento de diversas patologías cerebrales. Con objeto de integrar los datos existentes sobre el SRA cerebral y obtener sugerencias sobre su papel fisio-patológico, se ha llevado a cabo una revisión de la bibliografía más relevante y un análisis razonado de los principales conocimientos que hasta hoy en día existen sobre el tema.
Research about the renin-angiotensin system (RAS) has been focused on the role of the circulatory system on blood pressure control. However, recently it was demonstrated that the RAS components are not only in blood but also in other tissues such as brain where it has not only functions addressed to increase blood pressure but also participates in other brain functions including the cognitive ones. With a deep knowledge of brain RAS we will obtain suggestions about therapeutic possibilities not only for the treatment of hypertension but also for the treatment of brain disorders. In order to integrate the current knowledge of the brain RAS and to obtain suggestions on its physio-pathological role, a review of the most relevant references and an analysis of the major current knowledge of the subject has been performed.
Research about the renin-angiotensin system (RAS) has been focused on the role of the circulatory system on blood pressure control. However, recently it was demonstrated that the RAS components are not only in blood but also in other tissues such as brain where it has not only functions addressed to increase blood pressure but also participates in other brain functions including the cognitive ones. With a deep knowledge of brain RAS we will obtain suggestions about therapeutic possibilities not only for the treatment of hypertension but also for the treatment of brain disorders. In order to integrate the current knowledge of the brain RAS and to obtain suggestions on its physio-pathological role, a review of the most relevant references and an analysis of the major current knowledge of the subject has been performed.