Situación actual del desarrollo de resistencias a fármacos en Nematodos parásitos
Fecha
2025-05-12
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Jaén: Universidad de Jaén
Resumen
Diversas especies de nematodos gastrointestinales (Haemonchus contortus, Cooperia oncophora, Ostertagia ostertagi y Ascaris suum) tienen gran relevancia por cuanto afectan negativamente a animales del sector ganadero, particularmente vacas, cabras, ovejas, y cerdos. Este trabajo se ha centrado en la búsqueda bibliográfica sobre la resistencia de dichas especies, utilizando diversas bases de datos (entre otras Google Scholar. Pubmed y WOS) y las herramientas de búsquedas que estas permiten. Hacemos especial énfasis en la creciente problemática de la resistencia a fármacos. Este trabajo se ha centrado en la búsqueda bibliográfica sobre la resistencia que presentan y los mecanismos implicados. Mis resultados ponen de manifiesto cuales son los mecanismos de resistencia más relevantes, relacionados con el metabolismo y degradación de fármacos, o cambios en la estructura genética de las poblaciones implicadas. No obstante, es necesario desarrollar una estrategia que considere el uso responsable de dichos antihelmínticos. A pesar de la existencia de medidas para mitigar la farmacorresistencia, aún se necesita más investigación sobre la eficacia real y el impacto del uso combinado de antihelmínticos.
Several species of gastrointestinal nematodes (Haemonchus contortus, Cooperia oncophora, Ostertagia ostertagi, and Ascaris suum) are highly relevant because they negatively affect livestock animals, particularly cows, goats, sheep, and pigs. This work has focused on a literature search for resistance in these species, using various databases (including Google Scholar, PubMed, and WOS) and the search tools they provide. We place special emphasis on the growing problem of drug resistance. This work has focused on a literature search for their resistance and the mechanisms involved. My results reveal the most relevant resistance mechanisms, related to drug metabolism and degradation, or changes in the genetic structure of the populations involved. Although, is necessary to develop a strategy that takes into account the responsible use of anthelmintics. Despite the existence of measures to mitigate drug resistance, further research is still needed on the actual efficacy and impact of combined anthelmintic use.
Several species of gastrointestinal nematodes (Haemonchus contortus, Cooperia oncophora, Ostertagia ostertagi, and Ascaris suum) are highly relevant because they negatively affect livestock animals, particularly cows, goats, sheep, and pigs. This work has focused on a literature search for resistance in these species, using various databases (including Google Scholar, PubMed, and WOS) and the search tools they provide. We place special emphasis on the growing problem of drug resistance. This work has focused on a literature search for their resistance and the mechanisms involved. My results reveal the most relevant resistance mechanisms, related to drug metabolism and degradation, or changes in the genetic structure of the populations involved. Although, is necessary to develop a strategy that takes into account the responsible use of anthelmintics. Despite the existence of measures to mitigate drug resistance, further research is still needed on the actual efficacy and impact of combined anthelmintic use.